Explore the Agenda
8:00 am Registration Opens & Morning Coffee
8:50 am Chair’s Opening Remarks
Introducing the Discovery of LNPs & Novel Targeting Strategies for Achieving Potent Extrahepatic Delivery
9:00 am Panel Discussion: Delving into the Discovery & Evolution of LNPs to Gain an Understanding of the Foundation & Future Potential for LNP Delivery
- Uncovering the origins of LNP technology and how they were initially discovered
- Exploring the evolving role of LNPs from early gene delivery systems to their pivotal role in mRNA vaccine development
- Showcasing the key scientific breakthroughs that have shaped modern LNP design
9:30 am Providing an Introduction into Targeted LNPs for Organ & Cell-Specific Delivery Beyond the Liver
- Diving into the fundamentals of targeted LNP design, including ligand selection and surface modifications
- Reviewing the biological and formulation factors that influence tissue and cell specificity
- Analyzing current applications and early strategies used to enhance precision and reduce off-target effects
NEW COMPANY
10:00 am Morning Networking Break
Spotlighting the Foundations of Formulation, Process Development & Manufacturing for High Quality LNP Development
11:00 am Deep Diving into LNP Formulations to Uncover How Lipid Chemistry Shapes Effective Delivery & Therapeutic Success
- Breaking down the key components of LNPs, focusing on the functional roles of ionizable lipids, helper lipids, cholesterol, and PEG-lipids
- Examining the principles of designing ionizable lipids to learn what makes them effective
- Understanding how formulations are tailored to optimize stability, delivery efficiency, and payload compatibility
11:30 am Optimizing Pharmaceutical Properties of LNPs by Improving Composition & Components for Greater Potency
- Fine-tuning the structure and ratio of lipids to boost LNP delivery efficiency
- Tailoring the cargo to unlock higher efficacy
- Demonstrating how process optimization strengthens LNP stability, and ensures consistent pharmaceutical properties
12:00 pm Building a Foundation on LNP Process Development & Manufacturing to Achieve Product Consistency & Scalability
- Showcasing the core steps in LNP process development to successfully translate from formulation to final product manufacturing
- Highlighting the key parameters to assess that influence product quality and the critical quality attributes
- Exploring fundamental strategies to ensure scalability, batch consistency, stability, and regulatory readiness
NEW COMPANY
12:30 pm Lunch & Networking
Overcoming the Key Bottlenecks of IP, Toxicity & Batch-to-Batch Variability for Accelerating Safe LNP Drug Products
1:30 pm An Overview of the Intellectual Property Trends for LNPs Including New Targeting Technologies
- Managing the crowded patent landscapes to secure and navigate third party rights relating to lipids, formulations, and delivery innovations
- Delving into the targeting moieties and other technologies which are driving and evolving the IP landscape
- Discussing the analytical framework for protecting the IP generated by research teams
2:00 pm Roundtable Discussion: Navigating Common but Critical Challenges Associated with LNPs to Build a Robust Toolkit for Developing Safe, Stable & Consistent LNPs
- Tackling common safety challenges of LNPs to enable redosability for more effective therapies
- Discussing the causes and impact of batch-to-batch variability and gaining insights into practical approaches for improving consistency
- Evaluating best practices for improving LNP stability and formulation to ensure global availability
3:00 pm Evaluating LNP Biology to Understand the Fundamental Properties that Impact Delivery Efficiency for Maximized Efficacy
- Deep diving into how LNPs circulate, distribute, and interact with biological systems after administration
- Exploring the key characteristics influencing biodistribution, cellular uptake, and endosomal escape
- Delving into how to measure LNP efficacy to evaluate therapeutic performance