Arnab Rudra
Visiting Scientist Boston Children's Hospital
Arnab, an alumnus of the Indian Institute of Technology, Bombay, began his scientific journey in India before moving to the United States for graduate studies. Under the guidance of Dr. Gary Keck, he focused on the total synthesis of natural products, including bryostatin 1 and its analogues. Driven by a keen interest in the challenges of nucleic acid chemistry, he pursued postdoctoral research with Dr. Marc Greenberg at Johns Hopkins University. Since 2016, Arnab has been a key researcher at MIT Chemical Engineering, collaborating with Dr. Daniel Anderson and Dr. Robert Langer. His current work primarily involves glucose-responsive insulin and the delivery of nucleic acid therapeutics.
Seminars
- Development of a new degradable ionizable lipid, AMG1541, for mRNA vaccines that significantly enhances potency and enables similar protective immunity at 100-fold lower doses than current standards, while also reducing toxicity and improving clearance in vivo
- Enhanced protein expression in antigen presenting cells and enhanced germinal center reactions giving rise to antigen specific B cells
- Detailed structure-activity relationship studies to unravel mechanistic aspects
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