• Conventional ionizable lipid design approach is based on SAR model, innovative ionizable lipid structures are limited, SM-102 and Lipid-5 are still the benchmark for mRNA delivery
• Abogen has established a library of ionizable lipids with in vivo test results to train our in-house machine learning model and as the model matures, we have gradually switched from rational design to AI-driven ionizable lipid generation approach
• The AI-driven lipid generator has created some truly innovative structures that demonstrated superior properties not only in efficiency and safety, it may help to overcome some intrinsic limitations in LNPs during repeated i.v. dosing

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