As the brain and muscle remain key targets for LNP drug products, this workshop will explore the hurdles of the blood-brain barrier and broad muscle biodistribution. Gain insights and have proactive discussions into how to optimize LNP formulations to achieve efficient, specific and selective delivery to muscle and CNS targets. Topics include:

• Examining how to fine-tune LNP characteristics to enable efficient delivery across extensive muscle areas without compromising immunogenicity
• Uncovering ligand approaches for achieving selective LNP penetration across the blood–brain barrier
• Evaluating how dual-targeting strategies may navigate endothelial barriers to deliver payloads into muscle and brain