Building workflows to identify high performing targeting ligands and lipid components is essential for accelerating LNP development, however, ensuring speed is balanced with accuracy is vital. In this workshop, examine lipid type and ligand screening strategies and align these with complete targeted LNP formulations to enhance translation. Topics include:

• Exploring how to efficiently screen vast libraries of ligands for specificity, transfection, and immunogenicity
• Highlighting reliable strategies to identify lipids which will enable endosomal escape and extrahepatic delivery
• Improving targeted LNP screening to balance throughput with quality metrics like selectivity and safety