Fireside Chat: Bridging In Vitro/In Vivo Translation by Overcoming Limitations of Potency Assays & Animal Models to Accelerate Clinic Progress
- What key factors should guide the selection of cell lines to develop bioassays that best predict in vivo LNP potency?
- How to design quantitative assays that measure relevant payload expression levels for understanding biological activity?
- Which animal models provide the most reliable assessment of LNP potency and how to better address variability in biodistribution and protein corona formation between species?