Ionizable Lipids: The Secret Sauce of Effective mRNA Vaccines

  • Comprehensive analysis of lipid nanoparticle technology as the leading platform for mRNA vaccine delivery, examining current advancements and future directions
  • Strategic design and synthesis approaches for next-generation ionizable lipids that enhance mRNA delivery efficiency and cellular uptake
  • Systematic investigation of molecular architecture-function correlations in ionizable lipids to:
    • Enhance immunogenicity through improved antigen presentation
    • Minimize reactogenicity by reducing inflammatory responses
    • Improved thermostability of mRNA-LNPs for the long-term storage of mRNA vaccines

NEW DATA