Ionizable Lipids: The Secret Sauce of Effective mRNA Vaccines
- Comprehensive analysis of lipid nanoparticle technology as the leading platform for mRNA vaccine delivery, examining current advancements and future directions
- Strategic design and synthesis approaches for next-generation ionizable lipids that enhance mRNA delivery efficiency and cellular uptake
- Systematic investigation of molecular architecture-function correlations in ionizable lipids to:
- Enhance immunogenicity through improved antigen presentation
- Minimize reactogenicity by reducing inflammatory responses
- Improved thermostability of mRNA-LNPs for the long-term storage of mRNA vaccines
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