Novel Design of Ionizable Lipids & LNP Formulations for Nucleic Acid Delivery Leading to CAR Knock-In

  • Introduction of our proprietary ionizable lipid library in vivo
  • Ready-to-use LNP for ex vivo studies
  • Ex vivo Application-1: knock-out in human primary T cell
  • Ex vivo Application-2: pDNA delivery to human primary T cell
  • In vivo Application: extra-hepatic lipids which were found from ex vivo studies