LNP characterization – From LNP Formulation to Protein Corona in Human Serum
- The typical LNP production process, mixing nucleic acids with selected lipids, purification, and formulation, often yields heterogeneous particles with over 90% impurities when multiple payloads are used
- Another challenge is selecting the proper lipid or modifying the LNP surface to enable active targeting of cells, and when delivered into human blood the LNP becomes surrounded by a so-called protein corona
- To better understand these processes and enable improved LNP design, our company presents the PATfix LNP Switcher and LNP Corona, tools in pharma and biotech for next-generation LNPs which are rapidly becoming gold-standard