Targeted Delivery of Therapeutic Cargo to T Cells & HSC with Extrahepatic Tropism
- Antibody-Free Targeted Delivery via LNP Engineering: Our investigation into targeted delivery to T cells and hematopoietic stem cells (HSCs) using lipid nanoparticle (LNP) formulation modifications, supported by both in vitro and in vivo data, demonstrates the potential of antibody-free strategies for cell-specific mRNA delivery
- Ligand- and Antibody-Mediated Targeting Approaches: We also explored targeted delivery to T cells and HSCs using antibody or ligand conjugation methods, comparing their efficiency and specificity to non-antibody-based approaches
- Key Observations and Insights: We will share critical findings from both delivery strategies, including comparative performance, biodistribution, and implications for therapeutic applications