Mercedes Segura Gally

Targeted LNPs are continuing to advance and evolve to enable extrahepatic targeting. However, they are hindered by limited robust analytical strategies. During this workshop deep dive into reliable analytical methods for assessing ligand density, stability and aggregation for more consistent product quality. Topics include:

• Leveraging comprehensive analytics to quantify ligand density to determine uniformity and minimize heterogeneity
• Unlocking advanced analytical strategies to understand ligand stability, linker degradation and free ligands for safer targeted LNPs
• Implementing imaging techniques for assessing aggregation, structural integrity and surface functionalization