Saswata Karmakar
Director - Chemistry Sanofi
Dr. Saswata Karmakar is a distinguished scientist with over 15 years of expertise in nucleic acid-based diagnostic and therapeutic applications. His current focus is the Lipid Nano Particle (LNP) based-mRNA delivery at Sanofi’s mRNA Center of Excellence in Waltham, USA. Dr. Karmakar earned his Ph.D. in Chemistry from the University of Idaho and completed postdoctoral training at Stanford University under Prof. Eric Kool. His research focuses on developing innovative mRNA delivery platforms using novel ionizable lipids. His significant contributions to the field are reflected in his impressive publication record in numerous peer-reviewed scientific articles and patents spanning nucleic acid chemistry and LNP-mediated mRNA delivery.
As Director of Chemistry at Sanofi, Dr. Karmakar continues to drive advancements in mRNA technology that have potential applications in vaccines and therapeutics.
Seminars
- Uncovering the origins of LNP technology and how they were initially discovered
- Exploring the evolving role of LNPs from early gene delivery systems to their pivotal role in mRNA vaccine development
- Showcasing the key scientific breakthroughs that have shaped modern LNP design
- Comprehensive analysis of lipid nanoparticle technology as the leading platform for mRNA vaccine delivery, examining current advancements and future directions
- Strategic design and synthesis approaches for next-generation ionizable lipids that enhance mRNA delivery efficiency and cellular uptake
- Systematic investigation of molecular architecture-function correlations in ionizable lipids to:
- Enhance immunogenicity through improved antigen presentation
- Minimize reactogenicity by reducing inflammatory responses
- Improved thermostability of mRNA-LNPs for the long-term storage of mRNA vaccines
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