Zhaohua (Joe) Zhou
Seminars
Wednesday 8th April 2026
Integrating Mast Cell Bioassays into Safety & Immunogenicity Assessment of LNP-Based Therapeutics
9:00 am
- Demonstrating how mast cell bioassays can identify PEG-related and other allergic reactions caused by mRNA/LNP vaccines and LNP-enabled therapeutics
- Correlating specific LNP attributes, excipient profiles, and manufacturing variables with mast cell activation signatures that predict allergic reactions observed in clinical settings
- Establishing a practical framework for integrating mast cell bioassays into LNP formulation and process development workflows to enhance safety assessment, mitigate scale-up risks, and meet regulatory expectations for emerging LNP modalities
