Conference Day One: Tuesday, April 15
7:15 Check-In & Coffee with Light Breakfast
8:15 am Chair’s Opening Remarks
Deep Diving into the Greatest Bottlenecks in the LNP Field to Improve Dosing, Scaling & Delivery for Advancing More LNPs Towards Approval
8:30 am Industry Leaders’ Panel Discussion: Overcoming the Challenges of Toxicity, Extrahepatic Delivery & Scaling-Up in LNP Development to Accelerate a Wider Range of Therapeutics towards the Clinic
Synopsis
- What strategies are you implementing to enable greater cell specific delivery to targets outside of the liver?
- How does analytical development and manufacturing change for targeted LNPs to enable scale-up?
- What methods do you have in place to face the challenge of toxicity?
9:00 am Unlocking the Future of LNPs for Delivery of a Wide Range of Human Medicines
Synopsis
- Delving into the LNP landscape to unleash the latest and greatest LNPs in the field
- Addressing key bottlenecks which the LNP field is facing, including advancing LNPs for successful gene therapy delivery
- Uncovering the future potential for LNPs to deliver more human medicines
9:30 am Session Reserved for Serina Therapeutics
10.00 Morning Break & Speed Networking
Synopsis
This session is your opportunity to get face-to-face with many of the brightest minds working in the LNP field and establish meaningful business relationships to pursue for the rest of the conference. Also, don’t forget to enjoy some refreshments before we split off into the 3 different tracks: Analytical Development & Characterization, Formulation & Delivery & Process Development & Manufacturing.
Analytical Development & Characterization Track
Accomplishing Deeper Characterization with Improved Particle Analysis for Understanding LNP Surface Changes & Targeting Moieties
CHAIR - Anni Chang, Senior Scientist II, Excipients GSSD,
US Pharmacopeia
11:00am: Understanding the Distribution, Function, & Impact of Targeting Moieties for Deeper Characterization of Targeted LNPs (tLNPs)
- Characterizing the distribution of targeting moieties on tLNPs
- Strategies to assess the function of targeting moieties on tLNPs
- Interrogating how conjugation impacts tLNP properties
David Chu, Senior Director, Analytical Development, Capstan Therapeutics
11:30am: Roundtable Discussion: Delving into Flow Imaging Techniques for Enabling Single Particle Analysis to Better Characterize LNPs
- How to automate single particle analysis to make it more
time efficient - How to use single particle analysis for deeper analysis into
particle size and encapsulation efficiency - How do changes in the process affect each individual
particle?
12:00pm: Heightened Characterization Strategies of mRNA/ LNPs & the Power of NMR
- Heightened Characterization Roadmap for mRNA/LNP
Modalities - How NMR can support LNP Characterization
- A case study demonstrating how NMR can detect surface
LNP changes
Erika Jensen, Principal Scientist, Pfizer
12.30 Lunch Break & Networking
Improving Analytical Techniques for Assessing Quality, Stability & Encapsulation Efficiency Leading to Reduced Toxicity Challenges
1:30pm: Analytical Strategies to Understand LNP Quality & Stability
- Implementing MALs and HPLC into the analytical strategy for improved monitoring of LNPs
- Showcasing novel analytical methods have been developed to understand stability and predict shelf-life for targeted LNPs
- Evaluating assays which can be used to understand the degradation mechanisms of LNPs
Felipe Gazos Lopes, Associate Director, Analytical Development, Tessera Therapeutics
2:00pm: Session Reserved for Partner
Enquire Now - sponsor@hansonwade.com
2:30pm: Emerging Methods to Determine Encapsulation Efficiency of Large Payloads in LNP
- Overcoming the challenges of measuring encapsulation in LNPs to ensure the payload is successfully loaded
- Delving into emerging methods for determining encapsulation efficiency
- Showcasing an optimized Ribogreen assay for more accurate measurement of LNP encapsulation
Swathi Pullagurla, Senior Scientist, Gritstone Bio
3:00pm: Afternoon Networking Break & Scientific Poster Session
Contribute to the conversation and share your cutting-edge research with your fellow LNP community to showcase your breakthrough discoveries to a vast audience of experts. Register your place to submit an abstract for review to showcase your poster*
Evaluating Lipid Properties & Excipient Quality to Understand Key Parameters for Advancing High Quality & Stable LNPs
4:00pm: Delving into the Physicochemical Properties of Lipids to Improve Product Performance & Shelf-Life
- Add strategies for deeper characterization of lipids to understand their impact on the final product
- Showcasing the impact of the lipid component on shelf-life and sheer thinning/thickening
- Highlighting what we are yet to learn about the lipids for complete understanding
Magali Hickey, Head, LNP Process Development, Moderna
4:30pm: Showcasing USP’s Perspective on New Frontiers in Excipient Quality & Development, including for Developing Safe & Compliant LNPs
- Reviewing USP’s perspective on excipient quality and development
- Discussing opportunities for incorporating lactide (or lactic acid) and glycolide (or glycolic acid) (LG) polymers in nanoparticles for improved delivery of therapeutics and vaccines
- Highlighting USP’s work on phospholipids and providing
new updates
Peng Zhang, Principal Scientist, US Pharmacopeia
5:00pm: Ask the Speakers
Your unique opportunity to ask the speakers your burning questions from the previous sessions in a dedicated Q&A session.