Conference Day One: Tuesday, April 30, 2024

7:30 am Morning Coffee & Registration

8:15 am Chair’s Opening Remarks

Striving for Clarity Throughout Early-Stage Discovery Through to LNP Regulatory Submission

8:30 am Introducing the Story of LNPs, Evolution & Approval of Onpattro & Beyond

  • Muthiah Manoharan Senior VP, Innovation Chemistry & Alnylam Distinguished Scientist, Alnylam Pharmaceuticals

Synopsis

  • Sharing the discovery of MC3 and discussing the impact on LNP development 
  • Exploring the process of rapidly eliminating (biodegradable) LNPs 
  • Highlighting the importance of xxtra-hepatic targeting with LNPs to ensure pinpoint delivery

9:00 am Mapping the Roadmap to Discovery & Early Development of mRNA through Non-Viral Drug Delivery

  • Annette Bak Head of Advanced Drug Delivery, AstraZeneca

Synopsis

  • LNPs and other delivery systems overview including best use
  • Discovering and optimizing non-viral delivery systems fast and efficiently
  • Outline the process for translating them from interesting delivery concepts in discovery to functional clinical products

9:30 am Session Reserved for Cytiva

10:00 am Morning Break & Speed Networking

Track A: Screening & Delivery

Benchmarking Parameters for Lipid Selection to Ensure Efficient Sourcing

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11.15 am Repeatedly Injectable Ionizable Lipids with Reduced Immunogenicity & Inflammation Profiles

Jee-Young Park, Executive Director, MediciBio


11.45 am Session Reserved for ARETERNA


12.15 pm Deep Diving into the Complex Relationship Between Lipids & Payload to Stabilize the LNP

Miffy Cheng, Postdoctoral Fellow, University of British Columbia


12.45 pm Ask the Speakers

Your unique opportunity to ask the speakers your burning questions from the previous sessions in a dedicated Q&A session

Track B: Formulation & Delivery
Track C: Characterisation & Analytical Development
Track D: Process Development & Manufacturing

1:15 pm Networking Lunch Break

Track A: Screening & Delivery

Brainstorming the Breadth of Models Available to Convey LNP Functionality

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2.30 pm Debating the Best Proxy for In Vivo LNP Delivery Across a Variety of Animal Models

Hilary Danz, Senior Scientist, Sanofi mRNA Center of Excellence


3.00 pm Exploring the Translational Potential of Organoids as a Viable Model for LNPs

Tobias Raabe, Research Assistant Professor of Medicine, University of Pennsylvania


3.30 pm Ask the Speakers

Your unique opportunity to ask the speakers your burning questions from the previous sessions in a dedicated Q&A session

Track B: Formulation & Delivery
Track C: Characterisation & Analytical Development
Track D: Process Development & Manufacturing

4:00 pm Afternoon Networking Break & Poster Session

Foreshadowing the Future of LNP – Maximizing Machine Learning & Automated LNP Design

4:45 pm Innovating Formulating Techniques to Minimize LNP Liver Leakage with Pinpoint Organ Targeting

  • Chris Lai Chief Executive Officer and Co-Founder, Metis Pharmaceuticals

Synopsis

  • Revealing the physiological mechanisms contributing to hepatic accumulation 
  • Revolutionizing the formulation of LNPs to create a more targeted delivery vehicle through analysis of LNP composition
  • Balancing stability and specificity of targeting when developing unique LNP formulations with a variety of lipids and conjugates

5:15 pm Revolutionizing LNP Delivery Through Machine Learning Intel

Synopsis

  • Exploring existing datasets to determine a relationship between input and output parameters
  • Utilizing input data to establish required experimental conditions
  • Translating output data to showcase formulation behaviours of interest

5:45 pm Chair’s Closing Remarks

6:00 pm End of Conference Day One & Poster Session

6:00 pm Drinks Reception