Conference Day One & Two
A Snapshot of Our Conference Day One & Two Plenary Sessions
Introducing the Story of LNPs, Evolution & Approval of Onpattro & Beyond
• Sharing the discovery of MC3 and discussing the impact on LNP development
• Exploring the process of rapidly eliminating (biodegradable) LNPs
• Highlighting the importance of extra-hepatic targeting with LNPs to ensure pinpoint delivery
Mapping the Roadmap to Discovery & Early Development of mRNA through Non-Viral Drug Delivery
• LNPs and other delivery systems overview including best use
• Discovering and optimizing non-viral delivery systems fast and efficiently
• Outline the process for translating them from interesting delivery concepts in discovery to functional clinical products
Summary of Conference Day One & Conference Day Two Tracks & Benefits
Track A: Discovery & Screening:
- Navigating the complex lipid library
- Seeking the correct model to screen LNPs
- Understanding relationship between payload and LNP
- Maintaining control of biodistribution to reach previously undruggable targets
- Supercharging Automated Screening methods
Track B: Formulation & Delivery:
- Ensuring extra-hepatic LNP delivery with pinpoint organ targeting
- Formulating a stable LNP
- Reducing the occurrence of toxic outcomes upon formulation of LNPs
- Utilising machine learning & automation to formulate LNPs
- Analysing the advanced technology available to formulate next generation LNP drug products
Track C: Characterization & Analytical Development:
- Maximizing the advanced analytical technology available to drug developers currently
- Understanding the impact of empty LNPs and characterizing the occurrence of non -encapsulated LNPs
- Establishing consistent CQAs (Critical Quality Attributes) across LNP development
- Evaluating the PDI variance across an LNP sample
Track D: Process Development & Manufacturing:
- Understanding the temperature dynamics to ensure stability of LNPs
- Ensuring maximal Purity of LNPs throughout process development
- Limiting the loss of yield during filtration of the LNP drug product
- Turbocharging an efficient scale up of LNPs with a smooth transition between phase development
- Establishing consistency in the tech transfer of LNPs to standardize manufacture
Recommended job titles for this track:
LNP / Lipid Discovery, LNP Screening, Particle Engineering, LNP Chemistry
Recommended job titles for this track:
Pre-Formulation, Delivery, Formulation, Stability, Drug Substance
Recommended job titles for this track:
Analytical Development, Bioanalytical, Characterization, Assay Development
Recommended job titles for this track:
Manufacturing, GMP, CMC, QC, QA, Tech Transfer, MSAT, Process Development, Process Optimization, Drug Product
A Snapshot of Our Conference Day One & Two World Class Speakers
To Access the Full Details on the Main 2-day Agenda, Download the Full Event Guide